Focus on composition and function of microbiota. Leverage data to identify patients with and without advanced fibrosis.
Integrate different platforms, phenotypes, metabolomics, metratranscriptomics, metaproteomics, and microbiota. Use findings to characterize microbial functions in human liver disease.
Analyze the interactions of bacteria with fungal, archaeal, and viral microbiota, including bacteriophages in differing stages of liver disease.
Identify potential non-gut sources of systemic inflammation in patients with liver disease, including mouth and other parts of the body.
Look at effects of dietary and cultural practices on microbiota. Assess the effects of their modulation on outcomes in liver disease.
Examine the predictive power of the gut microbiota for clinical decision-making in liver disease.
Develop novel, patient-specific microbiota cocktails aimed at different etiologies and stages of liver disease.